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| Designed Peptides & Mimetics In the mid-1990s, Dr. Mayo initiated a study of ß-sheet-forming peptides using a variety of physical chemical tools, including nuclear magnetic resonance (NMR) and circular dichroism (CD) spectroscopies. Using basic principles of peptide folding and the ß-sheet scaffold known from previous research, a series of ß-sheet-forming peptide 33mers (bpep peptides) displayed excellent water solubility and structural stability under physiological conditions. Some designed bpep peptides had incorporated within their amino acid sequences key functional residues from antimicrobial and anti-angiogenic proteins, leading to the generation of the peptide leads discussed below.Other studies conducted by Dr. Mayo through the sponsorship of the pharmaceutical industry have led over the past 15 years to the identification of pharmacophore sites in several peptide drug leads. His success as a consultant to the pharmaceutical industry inspired him to channel his scientific efforts to the design of bioactive peptides and small molecules in his own lab at the University of Minnesota, and in the founding of PepTx along with a group of other scientists and business entrepreneurs. |
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